Apatite Bio Ceramic (Nano Freeze Dried Powder, CIM feedstock)

Apatite Bio ceramic APA-90

We have made apatite bio ceramic ball(diameter 10mm) by CIM, and confirmed performance of our Pearl core.（Patent No.2958579）
Please check SEM picture and properties below.
Left side of the picture is original apatite ball, Right side of the picture is apatite ball after pearl shell processing.

Sintered body

ナノパウダー焼結体 SEM picture(✕5000)

Nishimura No.		APA-90
Main Component		Ca3(PO4)2
Bulk Density	g/cm3	2.77
Bending Strenght	MPa	30

（Reference:Bulk density of pearl is 2.65）

Application

Pearl core material（Patent No.2958579）
Based on our testing, we have checked the performance of this unique material.

This material is expected to be used as a alternative bone.

Nano Powder

Pulverized sintered apatite by bead mill and freeze-drying.

For it applies to cosmetic/ toothpaste/Quasi drag, We received a safety test by JFRL(Japan Food Research Laboratories)

SEM Picture(✕5000)

Graph of grain size.(Left side is Accumulation rate, bottom is grain size, Right size is frequency rate)

Safety Test

For apply to cosmetic/ toothpaste/Quasi drag, We took a safety test by JFRL(Japan Food Research Laboratories)

Subject	Researching Laboratories	Test Content	Test Result	Notes
Safety Test	JFRL	Acute toxicity test (Rat,Both sexes)	(LD50)>5000mg/kg	5000mg/kg single dose, 14days Observation, OECD TG420(2001) conformity
		Primary skin irritation test (Rabbit）	(Primary irritating index) 0<Nonstimulating>	OECD TG404(2015) ISO10993-10:2010 conformity
		Agents for treatment of oral mucosa(Guinea pig）	(Visual observation) Not particular	Suspension 800mg/mL 4times/day×Straight for four days

CIM Apatite feedstock (Compound material for ceramic injection molding)

Mixed by Nishimura’s unique CIM binder with Apatite powder. Only thermal debinding is needed, no liquid/chemical debinding.